Whether it is metabolic diseases (diabetes, fatty liver disease), autoimmune disorders of GI tract (ulcerative colitis, crohn’s disease, EoE), skin (eczema, psoriasis) or joints (rheumatoid arthritis) or it is brain disorders like dementia and Alzheimer, inflammation plays a critical role.
Oxidative stress: Oxidative stress is a phenomenon caused by an imbalance between production and accumulation of oxygen reactive species (ROS) in cells and tissues and the ability of a biological system to detoxify these reactive products.
β-hydroxybutyrate (BHB): The ketone body β-hydroxybutyrate (BHB) is synthesized in the liver from fatty acids and represents an essential carrier of energy from the liver to peripheral tissues when the supply of glucose is too low for the body’s energetic needs, such as during periods of prolonged exercise, starvation, or absence of dietary carbohydrates. In addition to its activity as an energetic metabolite, BHB is increasingly understood to have cellular signaling functions. These signaling functions of BHB broadly link the outside environment to epigenetic gene regulation and cellular function, and their actions may be relevant to a variety of human diseases as well as human aging.
Lectins: Naturally occurring proteins that are found in most plants serve a protective function (plant defense) for plants as they grow. Many experts and research suggest that lectins cause increased gut permeability and drive autoimmune diseases and may even have a role in brain and nervous system disorders such as multiple sclerosis, MS, and Parkinson’s disease. Legumes, including beans, soybeans, and peanuts, host the most plant lectins, followed by grains and plants in the nightshade family (e.g.: tomatoes, potatoes, eggplants).
Omega-6 to Omega-3 ratio:
Many research show and scientists believe omega-6s are pro-inflammatory, while omega-3s are anti-inflammatory. The ratio of omega-6 to omega-3 for pre-industrial populations ranged from 4:1 to 1:4 but current American Standard Diet (SAD) is very high in omega-6. Here is a good explanation of this.
There is a great explanation of this at Healthline
Leaky gut: Leaky gut occurs when cracks or holes develop in the lining of the digestive system in conditions such as celiac disease, Crohn’s disease, and irritable bowel syndrome. Gluten is one of the major causes of leaky gut.
Inflammation facts and hypothesis
– Oxidative stress and accumulation of oxygen reactive species can lead to inflammation
– There are several inflammatory markers (at least 16) including C-reactive protein (CRP), sedimentation rate (ESR) and blood platelet count and white blood cells (WBC)
– Using medications to lower any one of these markers can potentially have undesired effect on the overall inflammatory response.
– Auto-antibodies that attack body’s own cells in case of auto-immune diseases, are produced in reaction to toxins like lactins that are allowed into the circulation via leaky gut.
– Strong hypothesis regarding consumption of foods containing high amount of omega-6 that is inflammatory. Typical omega-6 to omega-3 ratios for pre-industrial populations ranged from 4:1 to 1:4.
– In “nutritional ketosis” when a well-formulated ketogenic diet is followed, ketone body β-hydroxybutyrate (BHB) are produced that are anti-inflammatory. Rather than glucose metabolism that produces free radicals and cause oxidative stress.
Dietary Approaches to reduce inflammation
– Remove processed/packaged foods including seed/vegetable oils as they contain toxins and high omega-6
– Remove all grains specially gluten (wheat and rye) from diet
– Remove plans with high lectin contents, some of these are the nightshade vegetables (tomato, egg plant, peppers, .Cooking reduces lectins.
– To reduce oxidative stress, get adequate sleep (at least 7 hours) and avoid too much artificial light at night to preserve the circadian rhythms (physical, mental, and behavioral changes that follow a daily cycle. They respond primarily to light and darkness in an organism’s environment), spend time outdoor and under the sun without sunscreen and reduce stress.
– For a systematic approach to reduce inflammation, try a well-formulated ketogenic diet
- Stephen Phinney, MD, PhD – Inflammation, Nutritional Ketosis, and Metabolic Syndrome:
2) Dr. Stephen Phinney’s well-formulated ketogenic diet
3) Autoimmune protocol (AIP) diet:
4) Dr. Paul Mason – How lectins impact your health – from obesity to autoimmune disease:
- Posted in: Health Topics